What is a common side effect of calcium channel blockers related to blood pressure reduction?

Calcium channel blockers are primarily used to treat conditions like hypertension and angina by causing vasodilation and reducing cardiac workload. A well-documented side effect associated with the use of these medications, particularly the dihydropyridine class (e.g., amlodipine, nifedipine), is constipation. This effect occurs because calcium plays a role in the peristaltic movement of the intestines. When calcium channel blockers inhibit calcium influx in smooth muscle cells, it can lead to decreased motility in the gastrointestinal tract, resulting in constipation.

This side effect can be significant, especially since it may affect a patient's willingness to continue the medication if not managed appropriately. The mechanism of action in relation to both blood pressure reduction and gastrointestinal function helps explain the correlation between the use of calcium channel blockers and the occurrence of constipation. Understanding these pharmacological effects is critical for managing patient care effectively.